Rspo2^tm1Suda
Targeted Allele Detail

Summary

• Symbol: Rspo2^tm1Suda
• Name: R-spondin 2; targeted mutation 1, Toshio Suda
• MGI ID: MGI:3839444
• Gene: Rspo2 Location: Chr15:42884190-43034222 bp, - strand Genetic Position: Chr15, 16.73 cM
• Alliance: Rspo2^tm1Suda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146829
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 145 bp fragment of exon 2 was replaced with a neo cassette via homologous recombination. RT-PCR confirmed the absence of RNA expression in lungs from homozygous embryos. (J:146829)

Expression

In Mice Carrying this Mutation:	22 assay results
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rspo2 Mutation: 20 strains or lines available

References

• Original: J:146829 Yamada W, et al., Craniofacial malformation in R-spondin2 knockout mice. Biochem Biophys Res Commun. 2009 Apr 10;381(3):453-8
• All: 3 reference(s)