Dkkl1^tm1Ducy
Targeted Allele Detail

Summary

• Symbol: Dkkl1^tm1Ducy
• Name: dickkopf-like 1; targeted mutation 1, Patricia Ducy
• MGI ID: MGI:3839561
• Gene: Dkkl1 Location: Chr7:44856943-44861571 bp, - strand Genetic Position: Chr7, 29.19 cM
• Alliance: Dkkl1^tm1Ducy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146994
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 45 codons were replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on testis extracts. (J:146994)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dkkl1 Mutation: 13 strains or lines available

References

• Original: J:146994 Dakhova O, et al., Dickkopf-like1 regulates postpubertal spermatocyte apoptosis and testosterone production. Endocrinology. 2009 Jan;150(1):404-12
• All: 2 reference(s)