Smad7^tm1Shou
Targeted Allele Detail

Summary

• Symbol: Smad7^tm1Shou
• Name: SMAD family member 7; targeted mutation 1, Weinian Shou
• MGI ID: MGI:3839575
• Synonyms: Smad7^loxP
• Gene: Smad7 Location: Chr18:75500600-75529006 bp, + strand Genetic Position: Chr18, 51.06 cM, cytoband E2
• Alliance: Smad7^tm1Shou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145777
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 4, and a neo cassette with a 5' loxP site was inserted into exon 4. (J:145777)

Generation of the Smad7^tm1Shou and Smad7^tm1.1Shou alleles

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad7 Mutation: 53 strains or lines available

References

• Original: J:145777 Chen Q, et al., Smad7 is required for the development and function of the heart. J Biol Chem. 2009 Jan 2;284(1):292-300
• All: 4 reference(s)