Kmt2a^tm1.1Erns
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm1.1Erns
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1.1, Patricia Ernst
• MGI ID: MGI:3839794
• Synonyms: Mll12^lox, Mll1^F
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm1.1Erns page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147265
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3, and a floxed hygro cassette was inserted downstream of exon 3. Transient cre expression in ES cells was used to remove the hygro cassette. ES cells originally used to create this allele contained Mll1^tm1Sjk. (J:147266)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:147265 Jude CD, et al., Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell. 2007 Sep 13;1(3):324-37
• All: 20 reference(s)