Kmt2a^tm1.2Erns
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm1.2Erns
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1.2, Patricia Ernst
• MGI ID: MGI:3839795
• Synonyms: Mll1^deltaN
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm1.2Erns page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147265
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove exon 3. This exon codes for several nuclear targeting sequences. (J:147265)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:147265 Jude CD, et al., Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell. 2007 Sep 13;1(3):324-37
• All: 1 reference(s)