Gt(ROSA)26Sor^{tm2(sb11)Njen}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(sb11)Njen}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Nancy A Jenkins
• MGI ID: MGI:3839796
• Synonyms: RLS, Rosa26-LsL-SB11, RosaSBase^LsL
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(sb11)Njen} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146887
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J x 129

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter, Transposase)
• Mutation: Insertion
• Mutation details: The sleeping beauty transposase, sb11, preceded by a lox-stop-lox cassette expressing EGFP was inserted via homologous recombination. In the absence of Cre mediated recombination sb11 is not expressed. (J:146887, J:153656)

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm2(sb11)Njen}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:146887 Starr TK, et al., A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science. 2009 Mar 27;323(5922):1747-50
• All: 31 reference(s)