Hdlq58^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Hdlq58^C57BL/6J
• Name: HDL QTL 58; C57BL/6J
• MGI ID: MGI:3839808
• QTL: Hdlq58 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Hdlq58 interacts with Hdlq15 on chromosome 1. F2 animals homozygous for 129S1/SvImJ alleles at Hdlq15 and homozygous for C57BL/6J alleles at Hdlq58 display significantly increased plasma HDL concentration on CHOW diet.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:144089

Linkage analysis was performed on 528 animals from a (C57BL/6J x 129S1/SvImJ)F2 intercross to map QTL associated with plasma HDL levels on either a CHOW or atherogenic diet. F2 animals were fed a CHOW diet until 8 weeks of age and then placed on an atherogenic diet until 16 weeks of age. An array of 508 SNPs was used for genome scan. Plasma HDL is significantly higher in 129S1/SvImJ parental strain compared to C57BL/7J on CHOW and high fat diets, with a stronger effect observed in males compared to females. Several previously identified HDL QTL were detected in this study as well as several novel loci, some of which showed interactive effects.

Interaction was observed between Hdlq15 on mouse Chromosome 1 and a novel locus on mouse Chromosome 7 named Hdlq58 (HDL QTL 58). Homozygosity for 129S1/SvImJ-derived alleles at Hdlq15 and homozygosity for C57BL/6J-derived alleles at Hdlq58 confer significantly increased plasma HDL levels in male and female animals on CHOW diet. Hdlq58 did not display influence on HDL cholesterol as a single locus.

References

• Original: J:144089 Su Z, et al., Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. J Lipid Res. 2009 Jan;50(1):116-25
• All: 1 reference(s)