Hdlq60^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Hdlq60^C57BL/6J
• Name: HDL QTL 60; C57BL/6J
• MGI ID: MGI:3839812
• QTL: Hdlq60 Location: unknown Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Hdlq60 interacts with Hdlq15 on chromosome 1. Homozygosity for 129S1/SvImJ alleles at Hdlq15 in conjunction with at least one C57BL/6J allele at Hdlq60 confers significant increased plasma HDL concentration in animals fed an atherogenic diet.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:144089

Linkage analysis was performed on 528 animals from a (C57BL/6J x 129S1/SvImJ)F2 intercross to map QTL associated with plasma HDL levels on either a CHOW or atherogenic diet. F2 animals were fed a CHOW diet until 8 weeks of age and then placed on an atherogenic diet until 16 weeks of age. An array of 508 SNPs was used for genome scan. Plasma HDL is significantly higher in 129S1/SvImJ parental strain compared to C57BL/7J on CHOW and high fat diets, with a stronger effect observed in males compared to females. Several previously identified HDL QTL were detected in this study as well as several novel loci, some of which showed interactive effects.

A novel locus named Hdlq60 (HDL QTL 60) on mouse chromosome X was detected via interaction with Hdlq15 on chromosome 1. Homozygosity for 129S1/SvImJ-derived alleles at Hdlq15 in conjunction with at least one C57BL/6J-derived alleleat Hdlq60 significantly increased plasma HDL levels in males and females on an atherogenic diet. Hdlq60 displays peak linkage at 124 Mb(50 cM) on chromosome X near rs6205221. This QTL did not exhibit a single-locus effect on plasma HDL concentration.

References

• Original: J:144089 Su Z, et al., Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. J Lipid Res. 2009 Jan;50(1):116-25
• All: 1 reference(s)