Trp53bp2^tm1Cdlo
Targeted Allele Detail

Summary

• Symbol: Trp53bp2^tm1Cdlo
• Name: transformation related protein 53 binding protein 2; targeted mutation 1, Charles D Lopez
• MGI ID: MGI:3839864
• Synonyms: ASPP2^-
• Gene: Trp53bp2 Location: Chr1:182236737-182289997 bp, + strand Genetic Position: Chr1, 84.93 cM
• Alliance: Trp53bp2^tm1Cdlo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146764
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 10 - 17 were replaced with a floxed neo cassette via homologous recombination. Western blot analysis indicates about a 2-fold reduction in protein expression in MEFs, thymus and liver from heterozygous mice. (J:146764)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Trp53bp2^tm1Cdlo/Trp53bp2^tm1Cdlo	involves: 129S1/Sv * 129X1/SvJ * C57BL/6
ht2	Trp53bp2^tm1Cdlo/Trp53bp2^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6
cx3	Trp53^tm1Brd/Trp53^+ Trp53bp2^tm1Cdlo/Trp53bp2^+	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
cx4	Trp53bp2^tm1Cdlo/Trp53bp2^+ Tg(EmuSR-tTa)83Bop/0 Tg(tetO-MYC)36aBop/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Phenotypes:

Affected Systems	hm1	ht2	cx3	cx4
show or hide all annotated terms
cellular		√
abnormal cell cycle checkpoint function		√
endocrine/exocrine glands				√
increased T cell derived lymphoma incidence				√
hematopoietic system		√		√
increased T cell derived lymphoma incidence				√
abnormal T cell physiology		√
immune system		√		√
increased T cell derived lymphoma incidence				√
abnormal T cell physiology		√
mortality/aging	√
embryonic lethality, complete penetrance	√
neoplasm		√	√	√
increased tumor incidence		√	√
increased T cell derived lymphoma incidence				√
increased incidence of tumors by ionizing radiation induction		√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53bp2^tm1Cdlo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53bp2 Mutation: 53 strains or lines available

References

• Original: J:146764 Kampa KM, et al., Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4390-5
• All: 4 reference(s)