Trp53bp2^tm1Cdlo
Targeted Allele Detail

Summary

• Symbol: Trp53bp2^tm1Cdlo
• Name: transformation related protein 53 binding protein 2; targeted mutation 1, Charles D Lopez
• MGI ID: MGI:3839864
• Synonyms: ASPP2^-
• Gene: Trp53bp2 Location: Chr1:182236737-182289997 bp, + strand Genetic Position: Chr1, 84.93 cM
• Alliance: Trp53bp2^tm1Cdlo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146764
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 10 - 17 were replaced with a floxed neo cassette via homologous recombination. Western blot analysis indicates about a 2-fold reduction in protein expression in MEFs, thymus and liver from heterozygous mice. (J:146764)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53bp2^tm1Cdlo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53bp2 Mutation: 53 strains or lines available

References

• Original: J:146764 Kampa KM, et al., Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4390-5
• All: 4 reference(s)