Mre11a^tm1Dof
Targeted Allele Detail

Summary

• Symbol: Mre11a^tm1Dof
• Name: MRE11A homolog A, double strand break repair nuclease; targeted mutation 1, David O Ferguson
• MGI ID: MGI:3839938
• Synonyms: Mre11^H129N
• Gene: Mre11a Location: Chr9:14695971-14748421 bp, + strand Genetic Position: Chr9, 4.33 cM
• Alliance: Mre11a^tm1Dof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147247
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 5 was replaced with one in which a C to A substitution results in the amino acid substitution of histidine with asparagine at position 129 (p.H129N) in the encoded protein. This mutation occurs in nuclease motif III. A loxP site flanked neomycin resistance gene cassette was inserted into intron 5 and subsequently removed by transient cre expression in ES cells. (J:147247)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mre11a Mutation: 49 strains or lines available

References

• Original: J:147247 Buis J, et al., Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell. 2008 Oct 3;135(1):85-96
• All: 3 reference(s)