Mre11a^tm2.2Dof
Targeted Allele Detail

Summary

• Symbol: Mre11a^tm2.2Dof
• Name: MRE11A homolog A, double strand break repair nuclease; targeted mutation 2.2, David O Ferguson
• MGI ID: MGI:3839940
• Synonyms: Mre11^delta
• Gene: Mre11a Location: Chr9:14695971-14748421 bp, + strand Genetic Position: Chr9, 4.33 cM
• Alliance: Mre11a^tm2.2Dof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147247
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove the neo cassette and exon 5. This deletion causes a frame shift and generates multiple stop codons after eight amino acids. The absence of protein expression was confirmed in mouse embryonic fibroblast extracts. (J:147247)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mre11a Mutation: 49 strains or lines available

References

• Original: J:147247 Buis J, et al., Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell. 2008 Oct 3;135(1):85-96
• All: 3 reference(s)