Hdlq59^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Hdlq59^C57BL/6J
• Name: HDL QTL 59; C57BL/6J
• MGI ID: MGI:3839967
• QTL: Hdlq59 Location: unknown Genetic Position: Chr19, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Hdlq59 interacts with Hdlq18 on chromosome 12. Homozygosity for C57BL/6J-derived alleles at Hdlq18 and Hdlq59 confers significantly decreased plasma HDL concentration on a CHOW diet.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:144089

Linkage analysis was performed on 528 animals from a (C57BL/6J x 129S1/SvImJ)F2 intercross to map QTL associated with plasma HDL levels on either a CHOW or atherogenic diet. F2 animals were fed a CHOW diet until 8 weeks of age and then placed on an atherogenic diet until 16 weeks of age. An array of 508 SNPs was used for genome scan. Plasma HDL is significantly higher in 129S1/SvImJ parental strain compared to C57BL/7J on CHOW and high fat diets, with a stronger effect observed in males compared to females. Several previously identified HDL QTL were detected in this study as well as several novel loci, some of which showed interactive effects.

A novel locus on mouse Chromosome 19 named Hdlq59 (HDL QTL 59) displayed interaction with Hdlq18 on mouse chromosome 12. Homozygosity for C57BL/6J-derived alleles at Hdlq59 and Hdlq18 confers significantly decreased plasma HDL concentration in animals fed a CHOW diet. Hdlq59 is located at 47.2 Mb (47 cM) on chromosome 19 near rs3023496 and does not exhibit a single-locus effect on plasma HDL levels. Hdlq18 maps to 11.5 Mb (3 cM) on chromosome 12 near rs3717933.

References

• Original: J:144089 Su Z, et al., Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. J Lipid Res. 2009 Jan;50(1):116-25
• All: 1 reference(s)