Hdlq53^129S1/SvImJ
QTL Variant Detail

Summary

• QTL variant: Hdlq53^129S1/SvImJ
• Name: HDL QTL 53; 129S1/SvImJ
• MGI ID: MGI:3839974
• QTL: Hdlq53 Location: unknown Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: 129S1/SvImJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased plasma HDL concentration on an atherogenic diet compared to C57BL/6J. (J:144089)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Hdlq53 displays suggestive linkage to HDL concentration on an atherogenic diet.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:144089

Linkage analysis was performed on 528 animals from a (C57BL/6J x 129S1/SvImJ)F2 intercross to map QTL associated with plasma HDL levels on either a CHOW or atherogenic diet. F2 animals were fed a CHOW diet until 8 weeks of age and then placed on an atherogenic diet until 16 weeks of age. An array of 508 SNPs was used for genome scan. Plasma HDL is significantly higher in 129S1/SvImJ parental strain compared to C57BL/7J on CHOW and high fat diets, with a stronger effect observed in males compared to females. Several previously identified HDL QTL were detected in this study as well as several novel loci, some of which showed interactive effects.

A novel locus named Hdlq53 (HDL QTL 53) mapped to 15.6 Mb (2.8 cM) on mouse Chromosome 6 near rs13478640. This locus displays suggestive linkage to plasma HDL concentration on an atherogenic diet (LOD=2.9) with 129S1/SvImJ-derived alleles conferring increased plasma HDL values. The Hdlq53 95% confidence interval spans 6 Mb (2.5 cM) to 26 Mb (6 cM).

References

• Original: J:144089 Su Z, et al., Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. J Lipid Res. 2009 Jan;50(1):116-25
• All: 1 reference(s)