Hdlq55^129S1/SvImJ
QTL Variant Detail

Summary

• QTL variant: Hdlq55^129S1/SvImJ
• Name: HDL QTL 55; 129S1/SvImJ
• MGI ID: MGI:3839989
• QTL: Hdlq55 Location: unknown Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: 129S1/SvImJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased plasma HDL concentration on an atherogenic diet compared to C57BL/6J. (J:144089)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Hdlq55 displays suggestive linkage to plasma HDL concentration on an atherogenic diet.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:144089

Linkage analysis was performed on 528 animals from a (C57BL/6J x 129S1/SvImJ)F2 intercross to map QTL associated with plasma HDL levels on either a CHOW or atherogenic diet. F2 animals were fed a CHOW diet until 8 weeks of age and then placed on an atherogenic diet until 16 weeks of age. An array of 508 SNPs was used for genome scan. Plasma HDL is significantly higher in 129S1/SvImJ parental strain compared to C57BL/7J on CHOW and high fat diets, with a stronger effect observed in males compared to females. Several previously identified HDL QTL were detected in this study as well as several novel loci, some of which showed interactive effects.

A novel locus named Hdlq55 (HDL QTL 55) was identified at 100 Mb (47 cM) on mouse Chromosome 14 near rs6179144 with suggestive association to plasma HDL concentration on an atherogenic diet (LOD=2.9). 129S1/SvImJ-derived alleles at Hdlq55 confer increased plasma HDL concentration on an atherogenic diet. The 95% confidence interval for Hdlq55 spans 94 Mb (44.5 cM) to 117 Mb (54 cM).

References

• Original: J:144089 Su Z, et al., Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. J Lipid Res. 2009 Jan;50(1):116-25
• All: 1 reference(s)