Hdlq56^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Hdlq56^C57BL/6J
• Name: HDL QTL 56; C57BL/6J
• MGI ID: MGI:3839993
• QTL: Hdlq56 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased plasma HDL concentration in males on CHOW and atherogenic diets compared to 129S1/SvImJ. (J:144089)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Hdlq56 is a male-specific locus displaying suggestive linkage to plasma HDL levels on CHOW and atherogenic diets.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:144089

Linkage analysis was performed on 528 animals from a (C57BL/6J x 129S1/SvImJ)F2 intercross to map QTL associated with plasma HDL levels on either a CHOW or atherogenic diet. F2 animals were fed a CHOW diet until 8 weeks of age and then placed on an atherogenic diet until 16 weeks of age. An array of 508 SNPs was used for genome scan. Plasma HDL is significantly higher in 129S1/SvImJ parental strain compared to C57BL/7J on CHOW and high fat diets, with a stronger effect observed in males compared to females. Several previously identified HDL QTL were detected in this study as well as several novel loci, some of which showed interactive effects.

On mouse Chromosome 17, a novel male-specific QTL displaying suggestive linkage to plasma HDL concentration on CHOW (LOD=2.9) and atherogenic (LOD=2.7) diets mapped to 63.6 Mb (36 cM) near rs13483068. This locus spans 38 Mb (20.5 cM) to 86 Mb(54.6 cM) and is named Hdlq56 (HDL QTL 56). C57BL/6J-derived alleles at Hdlq56 confer increased plasma HDL concentration in male animals fed CHOW or atherogenic diets.

References

• Original: J:144089 Su Z, et al., Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. J Lipid Res. 2009 Jan;50(1):116-25
• All: 1 reference(s)