Hdlq57^129S1/SvImJ
QTL Variant Detail

Summary

• QTL variant: Hdlq57^129S1/SvImJ
• Name: HDL QTL 57; 129S1/SvImJ
• MGI ID: MGI:3839996
• QTL: Hdlq57 Location: unknown Genetic Position: Chr18, Syntenic

Variant origin

• Strain of Specimen: 129S1/SvImJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased plasma HDL concentration in females on a CHOW diet compared to 129S1/SvImJ. (J:144089)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Hdlq57 is a female-specific QTL.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:144089

Linkage analysis was performed on 528 animals from a (C57BL/6J x 129S1/SvImJ)F2 intercross to map QTL associated with plasma HDL levels on either a CHOW or atherogenic diet. F2 animals were fed a CHOW diet until 8 weeks of age and then placed on an atherogenic diet until 16 weeks of age. An array of 508 SNPs was used for genome scan. Plasma HDL is significantly higher in 129S1/SvImJ parental strain compared to C57BL/7J on CHOW and high fat diets, with a stronger effect observed in males compared to females. Several previously identified HDL QTL were detected in this study as well as several novel loci, some of which showed interactive effects.

On mouse Chromosome 18, a novel female-specific locus for plasma HDL levels on a CHOW diet mapped to 22.9 Mb (13 cM) near rs13483251 (LOD=3.8). The 95% confidence interval spans 10 Mb (4 cM) to 36 Mb (17 cM) and this QTL is named Hdlq57 (HDL QTL 57). 129S1/SvImJ-derived alleles at Hdlq57 confer increased plasma HDL concentration in females on a CHOW diet.

A previously identified QTL named Hdlq47 (HDL QTL 47) mapped distally at 52.4 Mb (25 cM) in linkage to plasma HDL concentration on a CHOW diet near rs3722312 (LOD=3.4). 129S1/SvImJ-derived alleles at Hdlq47 confer increased plasma HDL values. The 95% confidenceinterval for Hdlq47 spans 36 Mb (17 cM) to 63 Mb (37 cM).

05.18.2015 Curator Note: Because Hdlq47 was originally mapped in J:114073 using an (C57BL/6J x A/J)F2 intercross population, which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Hdlq102.

References

• Original: J:144089 Su Z, et al., Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. J Lipid Res. 2009 Jan;50(1):116-25
• All: 1 reference(s)