Nup155^{Gt(RRD107)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Nup155^{Gt(RRD107)Byg}
• Name: nucleoporin 155; gene trap RRD107, BayGenomics
• MGI ID: MGI:3840086
• Synonyms: Nup155^-
• Gene: Nup155 Location: Chr15:8138757-8190731 bp, + strand Genetic Position: Chr15, 3.82 cM, cytoband A2
• Alliance: Nup155^{Gt(RRD107)Byg} page

Mutation origin

• Mutant Cell Line: RRD107
• Germline Transmission: Earliest citation of germline transmission: J:147210
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The gene trap vector containing a beta-geo cassette inserted into intron 5. Insertion results in a truncated protein of only 217 amino acids (of 1391). A 50% reduction in protein expression was confirmed by western blot analysis on extracts from heterozygous mice. (J:147210)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRD107	CC199849 ; (MGI Seq Detail)	5' RACE	Chr15:8144961-8146002 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  14 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nup155 Mutation: 94 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:147210 Zhang X, et al., Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death. Cell. 2008 Dec 12;135(6):1017-27
• All: 2 reference(s)