Plk2^tm1Elan
Targeted Allele Detail

Summary

• Symbol: Plk2^tm1Elan
• Name: polo like kinase 2; targeted mutation 1, Elan Pharmaceuticals Inc
• MGI ID: MGI:3840104
• Gene: Plk2 Location: Chr13:110531580-110537378 bp, + strand Genetic Position: Chr13, 61.97 cM, cytoband D2.1
• Alliance: Plk2^tm1Elan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147239
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: All 14 exons were replaced with a neo cassette. The absence of transcript expression was confirmed by quantitative RT-PCR on cortical cultures. (J:147239)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plk2 Mutation: 30 strains or lines available

References

• Original: J:147239 Inglis KJ, et al., Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J Biol Chem. 2009 Jan 30;284(5):2598-602
• All: 6 reference(s)