Tg(Nes-cre/ERT2)73Lfp
Transgene Detail

Summary

• Symbol: Tg(Nes-cre/ERT2)73Lfp
• Name: transgene insertion 73, Luis F Parada
• MGI ID: MGI:3840184
• Synonyms: Nes73-CreER^T2, Nestin-CreER^T2
• Transgene: Tg(Nes-cre/ERT2)73Lfp Location: unknown
• Alliance: Tg(Nes-cre/ERT2)73Lfp page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Nes-cre/ERT2)73Lfp expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Nes (25491)

  Nes	(MGI:101784)

• Mutation details: The 5.6 kb of the rat 5' regulatory element and 668bp of the inverted second intron was used to drive inducible neural expression of cre. Four lines where created with lines 8 and 73 exhibiting inducible expression. Line 8 expression is leaky whereas line 73 expression is not. (J:147310)

Generation of a tamoxifen-inducibele Tg(Nes-cre/ERT2)73Lfp transgene.

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (rat) Summary of all recombinase alleles driven by Nes. Comparative matrix view of recombinase activities Alliance rat Nes gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:147310 Chen J, et al., Inducible site-specific recombination in neural stem/progenitor cells. Genesis. 2009 Feb;47(2):122-31
• All: 17 reference(s)