Myod1^{tm2.1(icre)Glh}
Targeted Allele Detail

Summary

• Symbol: Myod1^{tm2.1(icre)Glh}
• Name: myogenic differentiation 1; targeted mutation 2.1, David J Goldhamer
• MGI ID: MGI:3840216
• Synonyms: MyoD^iCre
• Gene: Myod1 Location: Chr7:46025898-46028516 bp, + strand Genetic Position: Chr7, 30.03 cM
• Alliance: Myod1^{tm2.1(icre)Glh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147304
• Parent Cell Line: D1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Myod1^{tm2.1(icre)Glh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myod1 (MGI:97275)

• Mutation details: A genomic fragment including 3 bp of 5' untranslated sequence, all of exon 1, and 47 bp of intron 1 was replaced with an improved Cre gene followed by two tandem SV40 polyA sequences and an frt flanked neo cassette. Flp mediated recombination then removed the neo cassette. (J:152867)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myod1 (mouse) Summary of all recombinase alleles driven by Myod1. Comparative matrix view of recombinase activities Alliance mouse Myod1 gene page

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myod1 Mutation: 23 strains or lines available

References

• Original: J:147304 Yamamoto M, et al., A multifunctional reporter mouse line for Cre- and FLP-dependent lineage analysis. Genesis. 2009 Feb;47(2):107-14
• All: 60 reference(s)