Ccn2^tm1Mga
Targeted Allele Detail

Summary

• Symbol: Ccn2^tm1Mga
• Name: cellular communication network factor 2; targeted mutation 1, Maureen Gannon
• MGI ID: MGI:3840270
• Synonyms: CTGF^lacZ
• Gene: Ccn2 Location: Chr10:24471340-24474581 bp, + strand Genetic Position: Chr10, 11.84 cM, cytoband A3-B1
• Alliance: Ccn2^tm1Mga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145696
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 3, 4 and a part of exon 5 coding for von Willebrand factor type C domain with a transmembrane domain-lacZ/neo cassette via homologous recombination. The neo selection minigene was flanked with LoxP sites. Resulting allele produces a Ctgf N terminus/beta-gal fusion protein. (J:145696, J:200671)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccn2 Mutation: 29 strains or lines available

References

• Original: J:145696 Crawford LA, et al., Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and {beta}-Cell Proliferation during Embryogenesis. Mol Endocrinol. 2009 Mar;23(3):324-36
• All: 5 reference(s)