Cyp1a^tm1.1Bra
Targeted Allele Detail

Summary

• Symbol: Cyp1a^tm1.1Bra
• Name: cytochrome P450, family 1, subfamily a cluster; targeted mutation 1.1, Christopher A Bradfield
• MGI ID: MGI:3840319
• Synonyms: Cyp1a1/Cyp1a2^tm1.1Bra, DREC^-
• Gene: Cyp1a Location: unknown Genetic Position: Chr9, Syntenic

Increased liver inflammation and decreased hydropic degeneration in MGI:3840320/MGI:3840320 mice in response to dioxin-induced toxicity

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147150
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intergenic deletion Mutation details: An frt flanked neo cassette followed by a loxP site were inserted upstream and a second loxP site was inserted downstream of a cluster of 7 dioxin responsive elements (DRE). These DREs regulate expression of both Cyp1a1 and Cyp1a2. The neo cassette and DRE cluster were then removed by Flp and Cre mediated recombination respectively. (J:147150)

Generation of the MGI:3840320 allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp1a Mutation: 0 strains or lines available

References

• Original: J:147150 Nukaya M, et al., The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4923-8
• All: 2 reference(s)