Grm5^tm1.1Jixu
Targeted Allele Detail

Summary

• Symbol: Grm5^tm1.1Jixu
• Name: glutamate receptor, metabotropic 5; targeted mutation 1.1, Jian Xu
• MGI ID: MGI:3840366
• Synonyms: mGluR5^loxP
• Gene: Grm5 Location: Chr7:87233376-87784115 bp, + strand Genetic Position: Chr7, 49.01 cM
• Alliance: Grm5^tm1.1Jixu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147275
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into intron 7, 720 bp downstream of exon 7, and a third loxP site was inserted upstream of exon 7 via homologous recombination. The neo cassette was then removed via Cre mediated recombination. (J:147275)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grm5 Mutation: 78 strains or lines available

References

• Original: J:147275 Xu J, et al., mGluR5 has a critical role in inhibitory learning. J Neurosci. 2009 Mar 25;29(12):3676-84
• All: 28 reference(s)