Grm5^tm1.2Jixu
Targeted Allele Detail

Summary

• Symbol: Grm5^tm1.2Jixu
• Name: glutamate receptor, metabotropic 5; targeted mutation 1.2, Jian Xu
• MGI ID: MGI:3840382
• Synonyms: mGluR5^del
• Gene: Grm5 Location: Chr7:87233376-87784115 bp, + strand Genetic Position: Chr7, 49.01 cM
• Alliance: Grm5^tm1.2Jixu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147275
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Grm5^tm1.2Jixu/Grm5^tm1.2Jixu	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
behavior/neurological	√
abnormal contextual conditioning behavior	√
abnormal cued conditioning behavior	√
abnormal latent inhibition of conditioning behavior	√
abnormal inhibitory learning	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm5 Mutation: 79 strains or lines available

References

• Original: J:147275 Xu J, et al., mGluR5 has a critical role in inhibitory learning. J Neurosci. 2009 Mar 25;29(12):3676-84
• All: 3 reference(s)