Bmper^tm1Cpat
Targeted Allele Detail

Summary

• Symbol: Bmper^tm1Cpat
• Name: BMP-binding endothelial regulator; targeted mutation 1, Cam Patterson
• MGI ID: MGI:3840517
• Gene: Bmper Location: Chr9:23134372-23396496 bp, + strand Genetic Position: Chr9, 9.55 cM, cytoband A4
• Alliance: Bmper^tm1Cpat page

Delayed branching morphogenesis and inadequately expanded alveoli in Bmper^tm1Cpat/Bmper⁺ lungs

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146800
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Exons 1 and 2 were replaced with an EGFP and MC1r/neo cassette. The absence of transcript expression was confirmed by western blot analysis on lungs and heart extracts. (J:146800)

Generation of the Bmper^tm1Cpat allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmper Mutation: 47 strains or lines available

References

• Original: J:146800 Kelley R, et al., A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J Cell Biol. 2009 Feb 23;184(4):597-609
• All: 6 reference(s)