Mecp2tm3.1Jae
Targeted Allele Detail
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Symbol: |
Mecp2tm3.1Jae |
Name: |
methyl CpG binding protein 2; targeted mutation 3.1, Rudolf Jaenisch |
MGI ID: |
MGI:3840525 |
Synonyms: |
Mecp2S421A;S424A |
Gene: |
Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
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Alliance: |
Mecp2tm3.1Jae page
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Germline Transmission: |
Earliest citation of germline transmission:
J:147157
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Exons 3 and 4 were replaced by a floxed neo/STOP cassette and exons containing nucleotide substitutions that result in the amino acid substitutions of alanine for serine at positions 421 and 424 (S421A;S424A). Cre-mediated recombination was used to remove the neo/STOP cassette.
(J:147157)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129/Sv * C57BL/6 | |
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Phenotypes: |
Affected Systems |
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behavior/neurological
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hyperactivity
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nervous system
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√
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increased brain weight
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mecp2 Mutation: |
41 strains or lines available
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Original: |
J:147157 Tao J, et al., Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4882-7 |
All: |
4 reference(s) |
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