Mecp2^tm3.1Jae
Targeted Allele Detail

Summary

• Symbol: Mecp2^tm3.1Jae
• Name: methyl CpG binding protein 2; targeted mutation 3.1, Rudolf Jaenisch
• MGI ID: MGI:3840525
• Synonyms: Mecp2^S421A;S424A
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^tm3.1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147157
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exons 3 and 4 were replaced by a floxed neo/STOP cassette and exons containing nucleotide substitutions that result in the amino acid substitutions of alanine for serine at positions 421 and 424 (S421A;S424A). Cre-mediated recombination was used to remove the neo/STOP cassette. (J:147157)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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ot1	Mecp2^tm3.1Jae/Y	involves: 129/Sv * C57BL/6

Phenotypes:

Affected Systems	ot1
show or hide all annotated terms Sex:
behavior/neurological	√
hyperactivity	√
nervous system	√
increased brain weight	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 41 strains or lines available

References

• Original: J:147157 Tao J, et al., Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4882-7
• All: 4 reference(s)