Lats1^tm1Noj
Targeted Allele Detail

Summary

• Symbol: Lats1^tm1Noj
• Name: large tumor suppressor; targeted mutation 1, Hiroshi Nojima
• MGI ID: MGI:3840659
• Synonyms: Lats1^deltaN
• Gene: Lats1 Location: Chr10:7556978-7592224 bp, + strand Genetic Position: Chr10, 2.29 cM, cytoband A1
• Alliance: Lats1^tm1Noj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147050
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon, encoding exons 1 through 117, was replaced with a pgk-neomycin resistance cassette via homologous recombination. Western blot analysis confirmed the expression of the truncated protein. (J:147050)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lats1 Mutation: 52 strains or lines available

References

• Original: J:147050 Nishioka N, et al., The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell. 2009 Mar;16(3):398-410
• All: 3 reference(s)