Hoxd^tm17Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxd^tm17Ddu
• Name: homeobox D cluster; targeted mutation 17, Denis Duboule
• MGI ID: MGI:3840830
• Synonyms: HoxD^(12-13)Fi
• Gene: Hoxd Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47366
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The 5 Kb intergenic region between Hoxd13 and Hoxd12 was replaced with the corresponding 3 Kb sequence from zebrafish. A 5' floxed neo cassette was removed in vitro. Whole mount in situ hybridization confirmed reduced expression of Hoxd12 but normal expression of Hoxd11 and Hoxd13. (J:47366)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd Mutation: 0 strains or lines available

References

• Original: J:47366 Kondo T, et al., Control of colinearity in AbdB genes of the mouse HoxD complex. Mol Cell. 1998 Jan;1(2):289-300
• All: 1 reference(s)