In(2Hoxd11;Itga6)1Ddu
Targeted Allele Detail

Summary

• Symbol: In(2Hoxd11;Itga6)1Ddu
• Name: inversion, Chr 2, Denis Duboule 1
• MGI ID: MGI:3840855
• Synonyms: HoxD^{Inv(HoxDRVIII-Itga6)}, Hoxd^split10-11
• Gene: In(2Hoxd11;Itga6)1Ddu Location: Chr2:71617230-74517360 bp Genetic Position: Chr2, Syntenic

Axial skeleton abnormalities in heterozygous and homozygous In(2Hoxd11;Itga6)1Ddu mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100298
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd and 129S2/SvPas

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Inversion
• In(2Hoxd11;Itga6)1Ddu involves 71 genes/genome features (Zakit, Gm25960, Gm11084 ...) View all
• Mutation details: A sequential targeted recombination-induced genomic (STRING) approach using parental strains Hoxd11^tm2.1Ddu and Itga6^tm1Son produced an inversion of a 7 cM region within a chromosome between Hoxd11 and Itga6. (J:100298)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any In(2Hoxd11;Itga6)1Ddu Mutation: 0 strains or lines available

References

• Original: J:100298 Spitz F, et al., Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes. Nat Genet. 2005 Aug;37(8):889-93
• All: 5 reference(s)