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Map3k3tm1Kuro
Targeted Allele Detail
Summary
Symbol: Map3k3tm1Kuro
Name: mitogen-activated protein kinase kinase kinase 3; targeted mutation 1, Tomohiro Kurosaki
MGI ID: MGI:3840862
Synonyms: MEKK3flox
Gene: Map3k3  Location: Chr11:105975439-106046272 bp, + strand  Genetic Position: Chr11, 68.89 cM
Alliance: Map3k3tm1Kuro page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147103
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was introduced into intron 10 and a floxed neomycin cassette was introduced into intron 11. Cre recombinase was transiently expressed in correctly targeted ES cells to remove the neomycin cassette, leaving exon 11 floxed. Exon 11 encodes the ATP-binding site (K391) essential for the kinase activity of the protein product. (J:147103)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k3 Mutation:  27 strains or lines available
References
Original:  J:147103 Shinohara H, et al., Regulation of NF-kappaB-dependent T cell activation and development by MEKK3. Int Immunol. 2009 Apr;21(4):393-401
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory