Map3k3tm1Kuro
Targeted Allele Detail
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Symbol: |
Map3k3tm1Kuro |
Name: |
mitogen-activated protein kinase kinase kinase 3; targeted mutation 1, Tomohiro Kurosaki |
MGI ID: |
MGI:3840862 |
Synonyms: |
MEKK3flox |
Gene: |
Map3k3 Location: Chr11:105975439-106046272 bp, + strand Genetic Position: Chr11, 68.89 cM
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Alliance: |
Map3k3tm1Kuro page
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Germline Transmission: |
Earliest citation of germline transmission:
J:147103
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A single loxP site was introduced into intron 10 and a floxed neomycin cassette was introduced into intron 11. Cre recombinase was transiently expressed in correctly targeted ES cells to remove the neomycin cassette, leaving exon 11 floxed. Exon 11 encodes the ATP-binding site (K391) essential for the kinase activity of the protein product.
(J:147103)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Map3k3 Mutation: |
27 strains or lines available
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Original: |
J:147103 Shinohara H, et al., Regulation of NF-kappaB-dependent T cell activation and development by MEKK3. Int Immunol. 2009 Apr;21(4):393-401 |
All: |
1 reference(s) |
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