Tg(Myh6-PRKAG2*N488I)4623Jse
Transgene Detail

Summary

• Symbol: Tg(Myh6-PRKAG2*N488I)4623Jse
• Name: transgene insertion 4623, Jonathan G Seidman
• MGI ID: MGI:3841167
• Synonyms: TG^N488I
• Transgene: Tg(Myh6-PRKAG2*N488I)4623Jse Location: unknown
• Alliance: Tg(Myh6-PRKAG2*N488I)4623Jse page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-PRKAG2*N488I)4623Jse expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRKAG2 (51422)

  Prkag2

  (MGI:1336153)

• Mutation details: The mouse promoter was used to drive cardiac-specific expression of the human gene with an T to A substitution at position 1553 that results in the amino acid substitution of asparagine with isoleucine at position 488 (N488I). Eight lines were created with line 4623 selected as the representative line. This line carried 20 copies of the transgene. (J:128648)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128648 Arad M, et al., Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation. 2003 Jun 10;107(22):2850-6
• All: 5 reference(s)