Dag1^tm2.1Kcam
Targeted Allele Detail

Summary

• Symbol: Dag1^tm2.1Kcam
• Name: dystroglycan 1; targeted mutation 2.1, Kevin P Campbell
• MGI ID: MGI:3841383
• Synonyms: DAG1^lox, T30mN
• Gene: Dag1 Location: Chr9:108082060-108141176 bp, - strand Genetic Position: Chr9, 59.08 cM
• Alliance: Dag1^tm2.1Kcam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156588
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was used to introduce a loxP site downstream of exon 2 and insert a floxed neo cassette in the upstream intron. Cre mediated recombination removed the neomycin cassette, leaving a loxP site in intron 1 and another 3' to the 3' UTR. (J:78838, J:156588)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dag1 Mutation: 109 strains or lines available

References

• Original: J:156588 Campbell K, Mice homozygous for a dystroglycan 1 mutation with exon flanked by loxP sites are viable and fertile and appear healthy. MGI Direct Data Submission. 2010
• All: 10 reference(s)