Tacr3^tm1Jasi
Targeted Allele Detail

Summary

• Symbol: Tacr3^tm1Jasi
• Name: tachykinin receptor 3; targeted mutation 1, Judith A Siuciak
• MGI ID: MGI:3841488
• Synonyms: NK3^-, NK3R^-
• Gene: Tacr3 Location: Chr3:134534768-134640340 bp, + strand Genetic Position: Chr3, 62.47 cM, cytoband H2
• Alliance: Tacr3^tm1Jasi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147538
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ reporter and neomycin resistance cassette replaced exon 1. Gene inactivation was confirmed by a lack mRNA in homozygote cerebral cortex as determined by RT-PCR. (J:147538)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tacr3 Mutation: 35 strains or lines available

References

• Original: J:147538 Siuciak JA, et al., Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits. Psychopharmacology (Berl). 2007 Oct;194(2):185-95
• All: 4 reference(s)