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Aqp7tm1Nlsn
Targeted Allele Detail
Summary
Symbol: Aqp7tm1Nlsn
Name: aquaporin 7; targeted mutation 1, Soren Nielsen
MGI ID: MGI:3841695
Gene: Aqp7  Location: Chr4:41033074-41048139 bp, - strand  Genetic Position: Chr4, 20.83 cM, cytoband B1
Alliance: Aqp7tm1Nlsn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147631
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 41 bp fragment from the middle of exon 5 was replaced with a neo cassette via homologous recombination. Immunoblot and immunohistochemical analysis confirmed the absence of protein expression in white adipose tissue, cardiac and skeletal muscle, testes, and kidneys from homozygous mice. (J:147631)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp7 Mutation:  24 strains or lines available
References
Original:  J:147631 Skowronski MT, et al., AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism. Am J Physiol Renal Physiol. 2007 Mar;292(3):F956-65
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory