Aqp7^tm1Nlsn
Targeted Allele Detail

Summary

• Symbol: Aqp7^tm1Nlsn
• Name: aquaporin 7; targeted mutation 1, Soren Nielsen
• MGI ID: MGI:3841695
• Gene: Aqp7 Location: Chr4:41033074-41048139 bp, - strand Genetic Position: Chr4, 20.83 cM, cytoband B1
• Alliance: Aqp7^tm1Nlsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147631
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 41 bp fragment from the middle of exon 5 was replaced with a neo cassette via homologous recombination. Immunoblot and immunohistochemical analysis confirmed the absence of protein expression in white adipose tissue, cardiac and skeletal muscle, testes, and kidneys from homozygous mice. (J:147631)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aqp7 Mutation: 24 strains or lines available

References

• Original: J:147631 Skowronski MT, et al., AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism. Am J Physiol Renal Physiol. 2007 Mar;292(3):F956-65
• All: 3 reference(s)