Cyp11b1^tm1Chjk
Targeted Allele Detail

Summary

• Symbol: Cyp11b1^tm1Chjk
• Name: cytochrome P450, family 11, subfamily b, polypeptide 1; targeted mutation 1, Christopher J Kenyon
• MGI ID: MGI:3841929
• Gene: Cyp11b1 Location: Chr15:74706741-74713492 bp, - strand Genetic Position: Chr15, 34.29 cM
• Alliance: Cyp11b1^tm1Chjk page

Cyp11b1^tm1Chjk/Cyp11b1^tm1Chjk mice display adrenal hypertrophy

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147610
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 7 were replaced with an IRES-ECFP and neo cassette. Immunohistochemistry confirmed the absence of protein expression in the zona fasciculata. (J:147610)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp11b1 Mutation: 25 strains or lines available

References

• Original: J:147610 Mullins LJ, et al., Cyp11b1 null mouse, a model of congenital adrenal hyperplasia. J Biol Chem. 2009 Feb 6;284(6):3925-34
• All: 1 reference(s)