Mir375^tm1Stf
Targeted Allele Detail

Summary

• Symbol: Mir375^tm1Stf
• Name: microRNA 375; targeted mutation 1, Markus Stoffel
• MGI ID: MGI:3842147
• Synonyms: 375KO
• Gene: Mir375 Location: Chr1:74939817-74939880 bp, - strand Genetic Position: Chr1, 38.54 cM
• Alliance: Mir375^tm1Stf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147572
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire 64 bp precursor sequence was replaced with a neo cassette and a dsRed cDNA via homologous recombination. No dsRed expression was detected. In situ hybridization and Northern blot analysis confirmed the absence of miRNA expression in pancreatic islets and other neuroendocrine tissues, respectively, from homozygous mice. (J:147572)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir375 Mutation: 1 strain or line available

References

• Original: J:147572 Poy MN, et al., miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5813-8
• All: 1 reference(s)