Flcn^{Gt(RRX115)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Flcn^{Gt(RRX115)Byg}
• Name: folliculin; gene trap RRX115, BayGenomics
• MGI ID: MGI:3842151
• Synonyms: Bhd^-
• Gene: Flcn Location: Chr11:59682234-59700842 bp, - strand Genetic Position: Chr11, 37.79 cM
• Alliance: Flcn^{Gt(RRX115)Byg} page

Mutation origin

• Mutant Cell Line: RRX115
• Germline Transmission: Earliest citation of germline transmission: J:147582
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Hypomorph)
• Mutation: Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap
• Mutation details: A Beta-geo gene trap vector inserted into intron 8. Truncation of the transcript was confirmed by RT-PCR analysis of ES cells. Heterozygote mice only had half the expression of full-length mRNA as determined by Q-PCR on kidney lysates. (J:147582)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRX115	CL903373 ; (MGI Seq Detail)	5' RACE	Chr11:59688883-59690264 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  12 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	64 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flcn Mutation: 42 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:147582 Hartman TR, et al., The role of the Birt-Hogg-Dube protein in mTOR activation and renal tumorigenesis. Oncogene. 2009 Apr 2;28(13):1594-604
• All: 4 reference(s)