Cyp11b2^tm2Hsk
Targeted Allele Detail

Summary

• Symbol: Cyp11b2^tm2Hsk
• Name: cytochrome P450, family 11, subfamily b, polypeptide 2; targeted mutation 2, Hyung-Suk Kim
• MGI ID: MGI:3842189
• Synonyms: AS^hi, Cyp11b2^tm2Unc
• Gene: Cyp11b2 Location: Chr15:74722859-74728167 bp, - strand Genetic Position: Chr15, 34.29 cM
• Alliance: Cyp11b2^tm2Hsk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147672
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The non-coding region of exon 9 was replaced with duplicate copies of the bovine growth hormone 3'UTR with its GU/U rich element and a floxed neo cassette. Transcript expression in homozygotes is increased 150% compared to in wild-type mice, as determined by RT-PCR. (J:147672)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp11b2 Mutation: 41 strains or lines available

References

• Original: J:147672 Makhanova N, et al., Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase. Hypertension. 2008 Jan;51(1):134-40
• All: 1 reference(s)