Sirt7^tm1Evbo
Targeted Allele Detail

Summary

• Symbol: Sirt7^tm1Evbo
• Name: sirtuin 7; targeted mutation 1, Eva Bober
• MGI ID: MGI:3842304
• Gene: Sirt7 Location: Chr11:120509197-120515840 bp, - strand Genetic Position: Chr11, 84.34 cM
• Alliance: Sirt7^tm1Evbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147652
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 9 were replaced with a floxed neo cassette. The absence of transcript expression was confirmed by RT-PCR and nothern blot analysis on heart extracts. (J:147652)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Sirt7^tm1Evbo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt7 Mutation: 20 strains or lines available

References

• Original: J:147652 Vakhrusheva O, et al., Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res. 2008 Mar 28;102(6):703-10
• All: 13 reference(s)