Krt10^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Krt10^M1Btlr
• Name: keratin 10; mutation 1, Bruce Beutler
• MGI ID: MGI:3842434
• Synonyms: Rough-fur
• Gene: Krt10 Location: Chr11:99276080-99280190 bp, - strand Genetic Position: Chr11, 62.92 cM
• Alliance: Krt10^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was discovered by its visible phenotype in progeny of a mutagenized male mouse. Sequence analysis of all the genes in the keratin gene cluster revealed an A to T transversion at nucleotide position 547 of the keratin 10 gene, in the first of the gene's eight exons, that results in replacement of a highly conserved glutamic acid by valine at amino acid position 172 of the keratin protein (E172V), in the first linker domain. (J:147340)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Krt10 Mutation: 32 strains or lines available

References

• Original: J:147340 Du X, et al., Record for "Rough-fur" updated April 14th, 2009. MGI Direct Data Submission. 2009
• All: 1 reference(s)