Ache^tm3Pata
Targeted Allele Detail

Summary

• Symbol: Ache^tm3Pata
• Name: acetylcholinesterase; targeted mutation 3, Palmer Taylor
• MGI ID: MGI:3842443
• Synonyms: AChE^{del E5/Neo}
• Gene: Ache Location: Chr5:137286516-137292728 bp, + strand Genetic Position: Chr5, 76.32 cM
• Alliance: Ache^tm3Pata page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147855
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 was replaced with a floxed neo cassette. Ache serum activity is dramatically reduced compared to in wild-type mice, but can be restored by removal of the floxed cassette. (J:147855)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ache Mutation: 30 strains or lines available

References

• Original: J:147855 Camp S, et al., Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion. Chem Biol Interact. 2005 Dec 15;157-158:79-86
• All: 1 reference(s)