Meg3^tm1Kono
Targeted Allele Detail

Summary

• Symbol: Meg3^tm1Kono
• Name: maternally expressed 3; targeted mutation 1, Tomohiro Kono
• MGI ID: MGI:3842511
• Gene: Meg3 Location: Chr12:109506879-109538163 bp, + strand Genetic Position: Chr12, 60.25 cM
• Alliance: Meg3^tm1Kono page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147577
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 10 kb region including exons 1 through 5 and all of the upstream differentially methylated region was replaced with a neo cassette via homologous recombination. (J:147577)

Expression

In Mice Carrying this Mutation:	294 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meg3 Mutation: 4 strains or lines available

References

• Original: J:147577 Takahashi N, et al., Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice. Hum Mol Genet. 2009 May 15;18(10):1879-88
• All: 2 reference(s)