Tg(Cdh5-cre)1Nmoc
Transgene Detail

Summary

• Symbol: Tg(Cdh5-cre)1Nmoc
• Name: transgene insertion 1, Naoki Mochizuki
• MGI ID: MGI:3842516
• Synonyms: VE-cad-Cre
• Transgene: Tg(Cdh5-cre)1Nmoc Location: unknown
• Alliance: Tg(Cdh5-cre)1Nmoc page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Cdh5-cre)1Nmoc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Cdh5

• Mutation details: A 2.5 kb fragment of the Cdh5 promoter region followed by the cre recombinase cDNA and the SV40 polyadenylation signal was inserted into the pBluescriptSKII plasmid. The transgene fragment was excised and microinjected into C57BL/6J fertilized oocytes. Three founder lines were obtained, All three showed no differences in reporter gene expression when crossed to EGFP or LacZ reporter mice. Line 1 with an estimated 2 copies of the Cdh5-cre transgene was analyzed further. (J:121366)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cdh5 (species not specified) Summary of all recombinase alleles driven by Cdh5. Comparative matrix view of recombinase activities

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:121366 Kogata N, et al., Cardiac ischemia activates vascular endothelial cadherin promoter in both preexisting vascular cells and bone marrow cells involved in neovascularization. Circ Res. 2006 Apr 14;98(7):897-904
• All: 8 reference(s)