Gnmt^tm1Ymac
Targeted Allele Detail

Summary

• Symbol: Gnmt^tm1Ymac
• Name: glycine N-methyltransferase; targeted mutation 1, Yi-Ming Arthur Chen
• MGI ID: MGI:3842652
• Gene: Gnmt Location: Chr17:47036590-47040091 bp, - strand Genetic Position: Chr17, 22.9 cM, cytoband C
• Alliance: Gnmt^tm1Ymac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147857
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 4 and part of exon 5 were replaced with a neo cassette. The absence of protein was confirmed by western blot analysis on hepatic lysate. (J:147857)

Disease models

Expression

In Mice Carrying this Mutation:	66 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnmt Mutation: 25 strains or lines available

References

• Original: J:147857 Liu SP, et al., Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology. 2007 Nov;46(5):1413-25
• All: 11 reference(s)