Il27^tm1Cua
Targeted Allele Detail

Summary

• Symbol: Il27^tm1Cua
• Name: interleukin 27; targeted mutation 1, Daniel J Cua
• MGI ID: MGI:3842663
• Synonyms: IL-27p28^-
• Gene: Il27 Location: Chr7:126188182-126194113 bp, - strand Genetic Position: Chr7, 69.18 cM
• Alliance: Il27^tm1Cua page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147706
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2 through 5 were replaced with a FRT-flanked neomycin resistance cassette. Gene inactivation was confirmed in homozygote bone marrow derived macrophages and dendritic cells by real-time PCR. (J:147706)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il27 Mutation: 22 strains or lines available

References

• Original: J:147706 Diveu C, et al., IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J Immunol. 2009 May 1;182(9):5748-56
• All: 3 reference(s)