Tg(RP23-65I14)1Jno
Transgene Detail

Summary

• Symbol: Tg(RP23-65I14)1Jno
• Name: transgene insertion 1, Jeffrey L Noebels
• MGI ID: MGI:3842797
• Synonyms: alpha1G-Tg1
• Transgene: Tg(RP23-65I14)1Jno Location: unknown
• Alliance: Tg(RP23-65I14)1Jno page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(RP23-65I14)1Jno expresses 3 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Abcc3 (MGI:1923658)
  mouse	Ankrd40 (MGI:1918702)
  mouse	Cacna1g (MGI:1201678)

• Mutation details: This transgene consists of the mouse BAC RP23-65114 (GenBank id AL64596) containing the full coding sequence for Cacna1g, Abcc3, and Ankrd40 along with the 5' end of 330000P08Rik and the 3' end of Spata20. This line has1 to 2 transgene copy integrations. Overexpression of Cacna1g in the brain was verified by quantitative RT-PCR and western blot analysis. (J:146431)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:146431 Ernst WL, et al., Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy. J Neurosci. 2009 Feb 11;29(6):1615-25
• All: 1 reference(s)