Tg(KRT5-Akt1*)Jmpa
Transgene Detail

Summary

• Symbol: Tg(KRT5-Akt1*)Jmpa
• Name: transgene insertion, Jesus M Paramio
• MGI ID: MGI:3842829
• Synonyms: BK5myrAkt
• Transgene: Tg(KRT5-Akt1*)Jmpa Location: unknown
• Alliance: Tg(KRT5-Akt1*)Jmpa page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-Akt1*)Jmpa expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Akt1 (MGI:87986)

• Tg(KRT5-Akt1*)Jmpa expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: The bovine promoter was used to drive epithelial-specific expression of a myristoylated mouse Akt1. Two lines were created (L60 and L84). (J:127302)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127302 Segrelles C, et al., Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis. Cancer Res. 2007 Nov 15;67(22):10879-88
• All: 3 reference(s)