Ihh^tm1.1Dcha
Targeted Allele Detail

Summary

• Symbol: Ihh^tm1.1Dcha
• Name: Indian hedgehog; targeted mutation 1.1, Danny Chan
• MGI ID: MGI:3842979
• Synonyms: Ihh^E95K
• Gene: Ihh Location: Chr1:74984474-74990831 bp, - strand Genetic Position: Chr1, 38.55 cM
• Alliance: Ihh^tm1.1Dcha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147878
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A 397G>A substitution was introduced into exon 1 and a floxed neo cassette was inserted into intron 1 via homologous recombination. Cre mediated recombination then removed the neo cassette leaving a single loxP site in intron 1. The point mutation results in a E95K mutation in the protein. (J:147878)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ihh Mutation: 22 strains or lines available

Notes

ES cell line = L4.

References

• Original: J:147878 Gao B, et al., A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature. 2009 Apr 30;458(7242):1196-200
• All: 3 reference(s)