Zc3h12a^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Zc3h12a^tm1Aki
• Name: zinc finger CCCH type containing 12A; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3843029
• Synonyms: Reg1^-
• Gene: Zc3h12a Location: Chr4:125012216-125021633 bp, - strand Genetic Position: Chr4, 58.1 cM
• Alliance: Zc3h12a^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147868
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 5 were replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on LPS-stimulated macrophage extracts. (J:147868)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zc3h12a Mutation: 35 strains or lines available

References

• Original: J:147868 Matsushita K, et al., Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature. 2009 Apr 30;458(7242):1185-90
• All: 8 reference(s)