Itga3^tm1Rdav
Targeted Allele Detail

Summary

• Symbol: Itga3^tm1Rdav
• Name: integrin alpha 3; targeted mutation 1, Ronald Davis
• MGI ID: MGI:3843044
• Synonyms: f(alpha3)
• Gene: Itga3 Location: Chr11:94935300-94967627 bp, - strand Genetic Position: Chr11, 59.01 cM
• Alliance: Itga3^tm1Rdav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147820
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 11 and a floxed neo cassette was inserted downstream of exon 18. Transient cre expression in ES cells removed the floxed neo cassette. (J:147820)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itga3 Mutation: 53 strains or lines available

References

• Original: J:147820 Chan CS, et al., Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Learn Mem. 2007 Sep;14(9):606-15
• All: 2 reference(s)